Rates of illness from Vibrio parahaemolyticus have steadily been increasing as other foodborne illnesses have been decreasing. In California, rates of vibriosis has increased by almost 40% between 2009 and 2012.1 Often, the primary culprit for V. parahaemolyticus exposure is from the consumption of raw oysters. As climate change drives changes in water temperature, salinity, and phytoplankton composition in estuarine environments, there is a growing concern for an increased prevalence of V. parahaemolyticus. Taken together, it is increasingly imperative to understand the prevalence and human health risks of V. parahaemolyticus from both a local and global perspective. My dissertation research, in collaboration with Southern California Coastal Water Research Project (SCCWRP), aimed to do just that.